One question I get asked a lot when it comes to cannabis, specifically regarding marijuana and hemp analysis, is: There are so many techniques to choose from, how do I know which one is best? I can’t emphasize enough that the Cannabis sativa plant has a complex...
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Maximize NPS analysis with accurate mass spectrometry
LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Unlock the benefits of nominal mass spectrometry for NPS analysis
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
What has the Echo® MS system done for the pharma industry? (And don’t just take our word for it!)
SCIEX was very proud to have an illustration of the Acoustic Ejection Mass Spectrometry (AEMS) technology that powers the Echo® MS system on the front cover of the Journal of the American Society for Mass Spectrometry in January 2023. The associated article—Ultrahigh-Throughput Intact Protein Analysis with Acoustic Ejection Mass Spectrometry—was co-authored by scientists from SCIEX and Merck.
Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS
Producing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand.
It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.
How does automatic calibration work on the QTOF, TripleTOF and ZenoTOF systems?
When you think about calibration of a mass spectrometer, there are actually two aspects to consider. There is the accuracy of the calibration (that it is correct when calibration is performed) and the stability or precision of the mass calibration (that it remains...
What is SWATH acquisition and what are the critical acquisition attributes?
In data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...
Controlling the M5 MicroLC system with SCIEX OS software using contact closure
Contact closure can be used to control external devices that are not directly controlled by SCIEX OS software. A sample batch is first created in the SCIEX OS software for MS acquisition, and then a similar batch is created on an external LC device with the required...
The risky business of aflatoxins in milk
If you’re in the dairy or food testing business, you know the threat aflatoxins pose. Aflatoxins are a type of mycotoxin produced by Aspergillus parasiticus, aspergillus flavus , and rarely aspergillus nomius.1 These are likely the most extensively researched group of mycotoxins because of their adverse health effects.2 What’s more, they are widely found in a variety of crops, namely maize, tree nuts, and spices. Believed to be primarily caused by rising temperatures and humidity, these naturally occurring fungi grow on crops in the field, or during storage of feed and raw materials, where they can potentially produce toxins that enter the food chain.
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
Due to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
Metabolism and Biotransformation – What Are You Missing?
Are you looking to improve your MetID studies? Want to achieve the productivity and throughput you need to keep your projects moving and have complete confidence that you’re not missing any low level or parent-like metabolites in your sample? In this blog, we’re...
Biologics Characterization: Intact and Subunit Mass Analysis
When All You Need Is Range – Mass Range, Dynamic Range, and the Complete Range Launching the best possible product in the shortest time possible is key for pharmaceutical companies like you. As you know, nearly every process throughout the biologics development cycle...
Now You Can Overcome Your Food and Environmental Testing Obstacles
How do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Unraveling the Metabolome
Dr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...
It’s Time to Stop Fraudulent Food Reaching the Consumer with LC-MS/MS
If you are reading this blog, it is likely that you are fully acquainted with food fraud, but let’s just take a moment to set the scene. Food fraud is by no means a new phenomenon and goes as far back as the middle ages, with the concept of tampering or...
Product Quality Assessments of Biotherapeutics Using LC-MS MAM
Why LC-MS MAM?The Liquid Chromatography-Mass Spectrometry Multiple Attribute Methodology (LC-MS MAM) is a technique that is quickly gaining traction in the development and manufacturing of biopharmaceuticals. But what exactly is MAM? As researchers describe in a...
Ion Formation Control Is the Key to Increasing System Robustness
Traditional mass spectrometry ionization methods such as electronic spray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), are popular methods for detecting the molecular weight of proteins, peptides, and other biologics. The reason being both...
Why You Need Mass Spec for Veterinary Drug Residue and Antibiotic Analysis
As hospitals struggle with increasingly hard-to-treat antimicrobial resistance (ARM) bacterial infections, related deaths now exceed 700,000 per year globally and are predicted to reach 10 million per year by 2050. There’s no denying that these statistics are both...
Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM)
The effort to fully characterize and release a biotherapeutic to the market can be onerous. Typically, many tests are required to identify and monitor various attributes of the final product in order to ensure the safety and efficacy of the drug. These product quality...
Solving the Mystery of Forensic Quantitative Analysis
Why You Need Differential Mobility Spectrometry for Forensic Mass Spec Analysis Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of...
Calling all Bioanalysts: We’re Making Bioanalytical Selectivity Challenges History
High selectivity is a key component of successful quantitative bioanalysis. As a bioanalyst, we need consistently accurate and robust quantitation of small molecule therapeutics and metabolites. Challenged by complicated matrix interferences, high baseline signal, and...
The Latest and Greatest for Improving Lipidomic Analysis by Mass Spectrometry
Differential Mobility Separation (DMS) resolves multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Lipidomics research has progressed rapidly in...
Out with the “If it Ain’t Broke, Don’t Fix it” Approach. In with Remote Monitoring.
Often by the time you’re aware of a problem, it’s too late, and disaster has already struck. You’re forced to pick up the pieces—downtime, reduced productivity and lost data. When your PC goes down, IT comes to the rescue. That’s a reactive approach. In many cases, IT...
Increase your Lab’s ROI with Remote Monitoring Service for SCIEX LC-MS Systems
Like most organizations, your lab is likely thinking about ways to reduce costs and maximize profits.If so, keep in mind that no matter your area of research, sample volume or locations, remote monitoring services can make a difference in yearly maintenance...
SWATH Acquisition: A Step Closer to Unravelling the Opioid Puzzle
Drug overdose has become one of the leading causes of death of Americans under 50. If that’s not bad enough, let’s put this into perspective. America makes up only 4% of the world population. In 2015, it recorded 52,400 drug-related deaths, which is about 27% of the...
Metabolomics Studies Benefit Biomedical Research
Professor Dr. Thomas Hankemeier, Head of the Division of Systems Biomedicine and Pharmacology, LACDRLACDR is a center of excellence for multidisciplinary research into drug discovery and development, with a strong focus on metabolomics. As part of its research...
Greater uptime equals higher productivity
In the old days, if you wanted to monitor your lab’s data, you would either remain by your instrument as long as it took to complete the sample run or dial-in via a telephone modem. Neither option, however, offered much in the way of enhancing productivity. Today’s...
Simplifying Polar Pesticides Within a Single Analysis
Glyphosate is a polar pesticide widely used as a garden herbicide. It is an ingredient in the world’s bestselling weed killer, which farmers consider one of their best solutions to their super weed problems. However, the chemical has become one of the most...
5 Applications That Benefit from a New Dimension in Selectivity
Mass spectrometry can provide exceptional sensitivity, selectivity, resolution, throughput, and mass accuracy, but certain applications demand additional levels of selectivity. This is where differential ion mobility technology comes in. It delivers highly-selective,...
Maximize the use of your software. Buy only what you need
The latest releases of Analyst Software 1.7 and SCIEX OS Software 1.4 introduce a new licensing model called concurrent licensing. If you want flexibility and cost savings when purchasing and using your processing software, concurrent licensing is for you. How does...