Factors that affect the reproducibility of your assay As scientists, we know our experiments must be reproducible. Without it, there is always doubt as to whether our data interpretations and conclusions are truly sound. With LC-MS/MS quantitative methods, high...
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Selecting an LC-MS system for quantitation of pharmaceutical drug development
We understand you are busy, needing to prioritize running instruments, reporting results and managing your laboratory to meet deadlines. We created a solution guide to explain how SCIEX systems fit in the drug development pipeline to save you time evaluating options.
Nitrosamines: Where are we now?
Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
High complexity of the lipidome
The complexity of the lipidome is diverse in the structure and there are many combinatorial isoforms that are available within nature. Currently, many different techniques are required to fully characterize a lipid molecule. What if you could do it in a single...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
SWATH Acquisition: A Step Closer to Unravelling the Opioid Puzzle
Drug overdose has become one of the leading causes of death of Americans under 50. If that’s not bad enough, let’s put this into perspective. America makes up only 4% of the world population. In 2015, it recorded 52,400 drug-related deaths, which is about 27% of the...
Greater uptime equals higher productivity
In the old days, if you wanted to monitor your lab’s data, you would either remain by your instrument as long as it took to complete the sample run or dial-in via a telephone modem. Neither option, however, offered much in the way of enhancing productivity. Today’s...
Simplifying Polar Pesticides Within a Single Analysis
Glyphosate is a polar pesticide widely used as a garden herbicide. It is an ingredient in the world’s bestselling weed killer, which farmers consider one of their best solutions to their super weed problems. However, the chemical has become one of the most...
5 Applications That Benefit from a New Dimension in Selectivity
Mass spectrometry can provide exceptional sensitivity, selectivity, resolution, throughput, and mass accuracy, but certain applications demand additional levels of selectivity. This is where differential ion mobility technology comes in. It delivers highly-selective,...
Screening Food for Allergens Using LC-MS/MS Analysis
Browse the shelves of any grocery store, and you may get a false sense of security when it comes to ingredient lists. As much as consumers want to trust labels, the truth is, food products could contain mislabelled ingredients, such that they trigger an allergic reaction with serious detrimental effects including discomfort, pain sickness and in some instances, death. Manufacturers, however, do not want to risk their reputation and consumer safety over a false label. As such, there must be some sort of verification to support such an action
4 Reasons Why Your Lab Needs Remote Monitoring
You know the drill, lab managers are always seeking new solutions to keep their labs running at peak performance and instrument or system disruptions can be detrimental. Wouldn’t it be nice if there were a way to connect to your lab from anywhere securely and to stay ahead of potential instrument problems? By using remote monitoring, labs are now able to respond to issues quickly and efficiently, productively reducing downtime.
Testing for a Variety of Bath Salts is a Necessity for Forensic Labs
To date, when it comes to testing urine or oral fluids in the workplace not all psychoactive substances can be detected due to evolving substitutions. As legislation changes, so too do chemical formulations. Therefore researchers, like the authors of the following publication, A Validated Method for the Detection of 32 Bath Salts in Oral Fluids, published by Oxford Academic, analyze compounds using the best available methods so they can cast a wider net.
Empowering Your Lab with a Proactive Approach
Do you stay in the lab day and night, waiting for a sample run to finish? Or do you set your instrument to run and trust that it will operate as intended while you are away? Is there a way you can have a support network behind you to help to ensure the smooth operation of your instruments?
Vitamin D Analysis Made Simple
Last month, Dr. Phil Levy, a clinician, professor, and researcher at Wayne State University, was invited to SCIEX to lecture on ‘Vitamin D Measurement and Implications for Patient Care.’ His message was simple and very clear: Vitamin D testing is here to stay!
What does World Food Day Mean to Food Scientists?
Did you know that the Food and Agricultural Organization of the United Nations (FAO), celebrates its founding each year on October 16 with World Food Day? You can explore their theme and commitment to ending hunger by 2030 here. As part of their, “Ten Facts You Need to Know about Hunger,” perhaps you may find it interesting that, “The world will need to grow 60 percent more food by 2050 to feed the growing population.”
Transform the Analytical Power of Your SCIEX Mass Spec with SelexION Technology
If you are working with complex assays that demand exceptionally selective quantitative and qualitative performance, sometimes even the most powerful LC-MS/MS technology can’t always cut it alone.
Fipronil Contamination in Eggs Update
Since my last blog, there has been an ongoing investigation into the widespread impact of contaminated egg products. According to The Grocer, 26 more egg foods were pulled from shelves in the fipronil scandal, bringing the total number to 69 products....
5 Ways That SelexION Technology Will Address Your Biggest Analytical Challenges
If you are a scientist working with complex assays, finding a way to significantly improve selectivity of detection could solve some of your biggest analytical headaches. Are we right? If so, then you are in the right place. If you are confronted with assay...
Why is Metabolomics Important and How is it Enabling Precision Medicine?
Why is metabolomics important?
Metabolomics is the large-scale study of metabolites in biofluids, tissue extracts, or organisms. Metabolites are small (<1000 Da), biologically active molecules such as glucose, cholesterol, creatinine, hormones, lipids, and more.
Training Program for Today’s Food and Beverage Testing Lab
Is your lab looking to acquire methods for food testing? What about getting better acquainted on the SCIEX Triple Quad™ or QTRAP® mass spectrometers to learn quantitation better? The following SCIEXUniversity Success Program training courses not only cover food and beverage quantitation but offer application training on topics such as meat speciation testing and pesticide analysis. Especially important considering the latest Fipronil contamination in eggs.I want to sign up for courses >
Phthalates Are Out, Accurate Detection Using LC-MS/MS Technology Is In
Whether you like it or not, the plastics industry is a growing market. According to an Allied Market Research report, it was valued at $15,179 million in 2015 and is projected to reach $18,538 million by 2022, growing at a CAGR of 2.9% from 2016 to 20221. Additionally, according to the report, in 2015, phthalates type held two-thirds of the global market in 2015. An important statistic since the use of various phthalates is restricted in many countries because of health concerns2.
Forensics Made Easy
Mass spectrometry techniques are now commonplace for high throughput quantitation and screening, but also for research and discovery for food safety, forensics, environmental testing, and a host of other applications. The demands of these settings are different from traditional research, requiring MS systems which combine robust and reliable operation with straightforward day-to-day processing. The SCIEX X500R QTOF System has been developed specifically to meet these needs and is now helping to streamline the workflow of Zurich’s Institute of Forensic Medicine.
3 Workflows Designed to Accelerate Your Biologics Characterization
Biopharmaceutical development is booming and now an integral part of many pharmaceutical company pipelines. While these emerging biologics present exciting opportunities for the industry, their sophistication is challenging the limits of characterization at all stages of discovery and development.
Making Your Vitamin D Testing Dreams Come True
If you work in clinical diagnostics, you can probably confirm that most clinical laboratories have seen a 5 to 6-fold increase in 25-hydroxyvitamin D testing over the past decade, and volume is growing. Furthermore, the Office of Inspector General (OIG) recently reported Vitamin D as one of the top five laboratory assays reimbursed by Medicare, accounting for 8.7 million laboratory tests and $337 million in reimbursement dollars.
The Science Behind SelexION Differential Mobility Spectrometry Technology
Scientists and analysts across all fields of testing and research are increasingly challenged by complex samples requiring advanced analytical selectivity. And where LC-MS/MS sensitivity alone is not enough to meet the demands of modern day quantitative performance, Differential Ion Mobility Spectrometry (DMS) has proven to be a valuable addition.