This excel workbook is designed to be used with data copied from a SCIEX OS software Analytics module results file
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Overcoming uncertainty in your PFAS analysis
Just like gum on the bottom of a shoe, the existence of per- and poly-fluorinated alkyl substances (PFAS) in our environment is a sticky one. If you’re in the field of environmental testing, then you’re all too familiar with the threat these substances have on public health. While we have learned a lot about them over the years, there is still much more to understand. With the right detection methods, we can gather the information we need to empower us to make informed decisions on reducing the risks they impose.
6 Signs it’s time for a new vendor
A lab’s success depends on many factors from instrument quality to efficient operations, including being partnered with the right vendor. A vendor is more than just a supplier. They should provide you with a high-level quality of support in maximizing the lifespan and performance of your systems, reducing downtime, enhancing ROI and more. How do you know if you’re partnered with the right one? Here are six signs it might be time to find someone new.
Selecting an LC-MS system for quantitation of pharmaceutical drug development
We understand you are busy, needing to prioritize running instruments, reporting results and managing your laboratory to meet deadlines. We created a solution guide to explain how SCIEX systems fit in the drug development pipeline to save you time evaluating options.
Nitrosamines: Where are we now?
Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
PFAS analysis in food: a robustness study in sensitivity and stability
The combination of per- and polyfluoroalkyl substances (PFAS) testing, trace-level regulatory requirements and complex MS applications can be intimidating. In a recent webinar, now available on demand, SCIEX PFAS expert Craig Butt demonstrated how the new SCIEX 7500+ system can help make PFAS testing easier.
Your success and voice go a long way!
At the heart of everything we do is ensuring that your workflows and team are empowered to achieve optimal results with your SCIEX instruments, software, consumables, and services. Every interaction with SCIEX is designed to support your success through the dedication...
FDA’s final rule on LDTs: what does it mean for clinical laboratories?
On April 29, 2024, the U.S. Food and Drug Administration (FDA) announced a final rule regulating laboratory developed tests (LDTs) as in vitro diagnostic devices (IVDs) under the Federal Food, Drug and Cosmetic Act (FD&C Act). This rule amends FDA’s regulations to state that in vitro diagnostic tests “manufactured” by clinical laboratories fall within the scope of the FDA regulatory oversight and is poised to dramatically shift the way clinical diagnostic laboratories in the United States develop and offer LDTs in the future. Read this blog post for a basic overview of the scope, intent and implications of this final rule, including the regulatory requirements, exceptions and timeline for implementation.
LC-MS system replacement: Are you ready?
Meeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?
An overview: LC-MS analysis of targeted protein degraders and their metabolites
Targeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.
Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Top 5 Analytical Challenges for Pesticides in Cannabis
Now that cannabis is legalized in a majority of the United States and Canada, new regulations to help protect consumers lead us to an important question: What are they getting? Here, we'll help provide the answer. Image source: Shayanne Gal/Business Insider Some of...
To Switch or Not to Switch? That is the Question.
Why Polarity Switching Matters The BasicsIn today’s busy analytical laboratories, productivity and high sample throughput are constant demands. More samples need to be analyzed in a shorter timeframe. Laboratories must work to use equipment at its maximum capacity,...
Improving precision
Factors that affect the reproducibility of your assay As scientists, we know our experiments must be reproducible. Without it, there is always doubt as to whether our data interpretations and conclusions are truly sound. With LC-MS/MS quantitative methods, high...
30 years of LC-MS/MS innovation continues
In 1989, the first commercial, dedicated Atmospheric Pressure Ionisation (API) tandem quadrupole mass spectrometry system was launched at the Pittsburgh Conference (PittCon) in Atlanta, Georgia (GA), USA. The API III, as it was called, was introduced to the analytical...
Drugs of Abuse Analysis: How LC-MS/MS Reduced Run Times by 66% and Tripled Throughput
Elevate Performance in Your Forensic Toxicology LabYou only need to skim through the United Nations World Drug Report 2018 to see that drug abuse is escalating. Associated with numerous medical, social, and legal problems, it comes as no surprise that ‘drugs of abuse’...
Same Pesticides, Same Risks, Different Standards
Should we be worried about our health because our produce contains pesticides? The answer very much depends on where in the world you live–or where your food comes from. When it comes to protecting people from harmful pesticide residues in food, standards around the...
3 Advantages of Clinical Mass Spectrometry
Are you thinking about replacing existing immunoassay technology with clinical mass spectrometry? Keep reading to discover how the 3 “S”s will help you make the decision. 1. How does sensitivity play a role? Many of the analytes measured in a clinical chemistry lab...
Detect the Signal, Not the Noise
Improving the specificity and selectivity of your assay Your LC-MS assay is only as good as its power to discern your target compound from everything else. Standards dissolved in clean solvents can make beautiful assays, but analytes in real-world samples can behave...
“There’s Nothing Wrong with a Little Bit of Mold.” WRONG!
Has anyone ever said to you, “There’s nothing wrong with a bit of mold”? No one likes to waste food, and it’s not unusual for people to scrape or pick mold off of foods before eating! Believe it or not, there’s guidance on foods that are (and are not) safe to eat if...
Top 4 reasons to try a SCIEX software subscription
Are you avoiding a software upgrade because of the cost? Just subscribe, sit back, and relax. The majority of SCIEX software solutions are now available as subscription products. For a price that is only 40% of the perpetual license fee, you can get access to more...
Improving Patient Care Through Translational Mass Spectrometry
Featuring: Wake Forest® Baptist Health Steven Wong, Ph.D., DABCC (TC), FACB, Past President AACC, Professor of Pathology, serves as Director of the Clinical Chemistry and Toxicology Core Laboratory and is Co-director of the Clinical and Translational Mass Spectrometry...
Software Licensing Comparison: Subscription or Perpetual?
Are you confused by software licensing? Do you want to know the difference between a subscription and a perpetual license? In this blog, we compare both options and explain the value of each choice for your laboratory. Years ago, the perpetual license model was the...
Make the Leap from GC to LC-MS/MS
Choosing the best technique for your analysis can be tough. Should you go with gas chromatography/mass spectrometry (GC-MS) or liquid chromatography/tandem mass spectrometry (LC-MS/MS)? That’s the key question. That’s why we’re here to help. The Limitations of...
Why Mass Spectrometry for Your Clinical Lab?
Aaron Hudson, VP/GM, Clinical Diagnostics, SCIEX Aaron Hudson is Vice President and General Manager, Clinical Diagnostics at SCIEX. Aaron has been with SCIEX for over 17 years, beginning as a Sales Representative, and holding various roles including Director Global...
Bad Leftovers: Antibiotic Residues in Food
We know that antibiotics used to treat livestock can end up in the food we eat. Routine food testing labs are essential for detecting compounds, like these, that can be dangerous to our health. Antibiotic residues include both parent molecules and metabolites left...
Canada’s Focus on Cannabis Quality and Safety Intensifies
The Second in a Three-Part Series Welcome to the second in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed and put you in the lead of the recently legalized cannabis market in Canada. In the first blog, we introduced the Cannabis...
Looking for Ethanol Metabolites and Barbiturates in Urine? Get the Fast and Sensitive ‘Two Bird, One Stone’ Method
Alcohol is legal and widely available, but it is an intoxicating and addictive substance that can have harmful effects on the human mind and body. It reduces inhibitions and distorts judgment and rational decision making, making it the number one cause of criminal...
Sensitivity, It’s at the Very Heart of Who We Are
Walk into any modern pharmaceutical company these days, and you’ll likely find at least one if not many, SCIEX LC-MS/MS instruments. Assays for the detection and quantitation of small molecule drugs, metabolites, biotherapeutics, biomarkers, and many other analytes...
The Advantages of a Software Maintenance Agreement
You’ve bought your mass spectrometer. You’ve installed all your hardware. You’ve got your operating software set up. You’ve mastered your software workflow modules to optimize quantitative and qualitative data processing. That’s it, right? Even though your system is...
You’ve Edited the Gene. Now What?
Protein-Level Verification Without The Need For Antibodies Using SWATH® Acquisition. Fast, Comprehensive, and Highly Reproducible Although humans have been able to influence the traits of plants and animals for thousands of years through domestication and selective...