The economics of food testing: A strategic perspective for laboratory managers by Philip Taylor | 0 CommentsIn today’s rapidly evolving food industry, the role of food testing laboratories has never been more critical. Ensuring the safety, quality, and authenticity of food products is paramount, and this responsibility falls heavily on the shoulders of laboratory managers. The economics of food testing—encompassing everything from high-throughput pesticide screening to advanced research on alternative protein sources—plays a pivotal role in shaping the operational efficiency and financial health of these laboratories.
Six benefits of remote support every laboratory should know by Andrea Mueller | 0 CommentsImagine having a tech expert at your fingertips to solve computer issues or a fitness trainer guiding you through workouts from the comfort of your home. In today’s fast-paced world, the ability to provide and receive service and support remotely is no longer a luxury but a necessity. Whether it’s troubleshooting a software issue, repairing a device, offering customer assistance, or enjoying the convenience of telehealth as a private individual, remote capabilities have revolutionized how businesses operate and how individuals get help
Advancing immunopeptidomics for pancreatic cancer research with ZT Scan DIA by Katherine Tran | 0 CommentsPancreatic cancer remains one of the most fatal types of cancer, and the rates of occurrences and mortalities continue to be on a global rise.1,2 Recent statistics have reported that the diagnosis of pancreatic cancer is the eighth most common type of cancer and...
Application of CGE in cell and gene therapy by Kerstin Pohl | 0 CommentsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
The economics of food testing: A strategic perspective for laboratory managers by Philip Taylor | BioPhase 8800 system, Blogs, Food / Beverage, Food and Beverage, Intabio ZT system, ZenoTOF 7600 system, ZenoTOF 7600+ systemIn today’s rapidly evolving food industry, the role of food testing laboratories has never been more critical. Ensuring the safety, quality, and authenticity of food products is paramount, and this responsibility falls heavily on the shoulders of laboratory managers. The economics of food testing—encompassing everything from high-throughput pesticide screening to advanced research on alternative protein sources—plays a pivotal role in shaping the operational efficiency and financial health of these laboratories.
Six benefits of remote support every laboratory should know by Andrea Mueller | Biopharma, Blogs, Environmental / Industrial, Food / Beverage, Food and Beverage, Forensic, Instrument maintenance, Life Science Research, Optimizing Performance, Pharma, Service, Support, Technology, TrainingImagine having a tech expert at your fingertips to solve computer issues or a fitness trainer guiding you through workouts from the comfort of your home. In today’s fast-paced world, the ability to provide and receive service and support remotely is no longer a luxury but a necessity. Whether it’s troubleshooting a software issue, repairing a device, offering customer assistance, or enjoying the convenience of telehealth as a private individual, remote capabilities have revolutionized how businesses operate and how individuals get help
Advancing immunopeptidomics for pancreatic cancer research with ZT Scan DIA by Katherine Tran | Blogs, Life Science ResearchPancreatic cancer remains one of the most fatal types of cancer, and the rates of occurrences and mortalities continue to be on a global rise.1,2 Recent statistics have reported that the diagnosis of pancreatic cancer is the eighth most common type of cancer and...
Application of CGE in cell and gene therapy by Kerstin Pohl | Biopharma, BioPhase 8800 system, BlogsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
From exposure to discovery: How SWATH DIA can enhance our understanding of the exposome and its impact on health by Rebekah Sayers | Blogs, Life Science Research, ZenoTOF 7600 systemLast year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
PFAS testing: 2024 in review and what to expect for 2025 by SCIEX Community | Blogs, Environmental / IndustrialFor as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | Blogs, Discovery, Echo MS, Pharma, QA/QCOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Unveiling the power of ZT Scan DIA: Insights from Ludwig Sinn’s presentation at World HUPO Congress 2024 by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600 systemIn a recent presentation at the World HUPO Congress 2024, Ludwig Sinn from the Ralser lab shared exciting advancements in proteomics research, focusing on the innovative ZT Scan DIA acquisition modes developed in collaboration with SCIEX. Let us explore the key highlights and benefits of this innovative technology.
Exploring the power of ZT Scan DIA by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600+ systemIn a recent presentation, Tim Heymann from Mann Lab at the Max Planck Institute of Biochemistry shared his first impressions of ZT Scan DIA, the novel data-independent acquisition strategy from SCIEX, highlighting its innovative approach and significant benefits for proteomics research. Let’s dive into the key points from his insightful talk.
Inside the box: Complementary fragmentation with LC-MS for Metabolite Identification by Kirsten Craven | Blogs, Pharma, ZenoTOF 7600 systemLiquid chromatography-mass spectrometry is commonly used for Met ID but confident soft spot identification is not always possible. Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
Tips and tricks from our application experts: AAV analysis with CE by Peter Holper | Biopharma, BioPhase 8800 system, Blogs, PA 800 systemPeter Holper, Staff Applications Scientist at SCIEX, US, shares his tips and tricks on AAV analysis using CE with the BioPhase 8800 system and the PA 800 Plus system.
Overcoming uncertainty in your PFAS analysis by Karl Oetjen | Blogs, Environmental / IndustrialJust like gum on the bottom of a shoe, the existence of per- and poly-fluorinated alkyl substances (PFAS) in our environment is a sticky one. If you’re in the field of environmental testing, then you’re all too familiar with the threat these substances have on public health. While we have learned a lot about them over the years, there is still much more to understand. With the right detection methods, we can gather the information we need to empower us to make informed decisions on reducing the risks they impose.
High mass tuning calibration for ZenoTOF 7600 by Gregg Czerwieniec | Bio Tool Kit, Development, Questions, ZenoTOF 7600 systemHi,
Metabolite identification and peace of mind by Kirsten Craven | Blogs, LC, Pharma, QTRAP / Triple Quad, ZenoTOF 7600 systemManaging metabolite identification (Met ID) studies is challenging, so what is at the top of your priority list as you plan the year ahead? Ensuring you have the data needed to manage product safety, meeting deadlines, staff recruitment and training, maintaining compliance, capital expenses, or something else?
Optimized rolling collision energy curves for IDA and SWATH DIA for peptides by Christie Hunter | Data acquisition, Life Science Research, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemDuring data dependent acquisition (DDA or IDA) or SWATH acquisition, the collision energy can be automatically adjusted according to the mass/charge and charge of the peptide. This dependency has been well characterized on our QTOF systems. By selecting rolling...
Current proteomics software compatibility for ZenoTOF 7600 system by Christie Hunter | Data processing, Life Science Research, Proteomics, SCIEX information, ZenoTOF 7600 systemBelow is a summary of various other software packages that are useful for processing proteomics data from the ZenoTOF 7600 system. Note this list is not comprehensive and only covers the tools we have lightly tested to date. Acquisition Type Software Files needed...
Processing ZenoTOF 7600 system data with DIA-NN software by Christie Hunter | Data processing, Life Science Research, Proteomics, SCIEX information, ZenoTOF 7600 systemDIA-NN software is a powerful software tool for processing data independent acquisition (DIA) proteomics datasets. It uses neural networks and other algorithms to identify and quantify peptides and proteins from DIA data and is specifically optimized for fast...
Excel macro for calculating averages or percent CVs from replicates in a 384 -well plate by Mackenzie Pearson | Bioanalysis/PK, Data processing, Data Visualization, Echo MS, Pharma, SCIEX information, SCIEX OS softwareThis excel workbook is designed to be used with data copied from a SCIEX OS software Analytics module results file
Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS by Alex Liu | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, PharmaProducing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand. It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.
How do I check the quality of the Auto Retention Time Calibration used in my Extractor processing? by Christie Hunter | Data Visualization, Life Science Research, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemWhen using the Auto-Calibration option in Extractor, a set of retention time calibration peptides will be determined automatically from the library and used for RT calibration. To determine how the fit looks for the calibration on each datafile, follow these steps....
Uploading data for use in OneOmics suite by Alexandra Antonoplis | Data processing, Life Science Research, Metabolomics, Multi-Omics, OneOmics, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemThere are two options for data storage when working with the OneOmics suite. You can store your data either within the SCIEX Cloud platform in the Data Store, or you can store data in BaseSpace (Illumina) and link your BaseSpace account with the SCIEX Cloud platform....
sMRM Pro Builder template tutorial by Mackenzie Pearson | Data processing, Data Visualization, How-to videos, Life Science Research, Lipidomics, Metabolomics, Optimizing Performance, QTRAP / Triple Quad, ResultsThe sMRM Pro Builder template is an Excel-based tool that can help you implement large panels of analytes in your lab. The Excel sheet will take your preliminary experimental results and compute retention times, retention time window widths and dwell time weighting to optimize your targeted assay.
Short-chain PFAS compounds are on the rise- Craig’s PFAS Vodcast Cora Young by Craig Butt | Blogs, Environmental / IndustrialRead time: 2 minutes Short-chain per- and polyfluoroalkyl substances (PFAS) are increasing in the Canadian Arctic environment, with the most rapid increases occurring post-2000, according to a recent study in Geophysical Research Letters (April 2020). For example,...
Thailand cannabis legalization by Diana Tran | BlogsThailand has become the first southeast Asian country to legalize cannabis for medical use. Cannabis was originally introduced into Thailand from India, and until it was outlawed in the 1930s, it was historically used as a kitchen condiment, medicine and source of fiber.
Reducing PFAS interferences during human plasma and serum analysis with accurate mass spectrometry by Ella Fono | Application / Technical Notes, Featured Content
High level method optimization considerations for Echo MS system by Mackenzie Pearson | Biopharma, Data acquisition, Echo MS, Environmental / Industrial, Food / Beverage, Life Science Research, Optimizing Performance, Pharma, SCIEX information, TechnologyWhile an in-depth discussion of method development and optimization for the Echo® MS system is beyond the scope of a community post, here are some points to consider as part of the process: The maximum recommended ion spray voltage for prolonged electrode life is 5000...
High complexity of the lipidome by Mackenzie Pearson | Data acquisition, Food / Beverage, How-to videos, Life Science Research, Lipidomics, ZenoTOF 7600 systemThe complexity of the lipidome is diverse in the structure and there are many combinatorial isoforms that are available within nature. Currently, many different techniques are required to fully characterize a lipid molecule. What if you could do it in a single...
Standard front-end cleaning for TripleTOF systems by Christie Hunter | Instrument maintenance, QTOF, SCIEX information, TechnologyGeneral points: Use of laboratory deionized (DI) water is specified at points in the procedure. However, if there are any concerns regarding quality, please utilize a reputable supplier of pure deionized water (>18.2M ohm). 5-10 liters will typically be required...
Stay informed on the latest novel psychoactive substances (NPS) flooding the US drug market by Pierre Negri | Forensic, QTOF, QTRAP / Triple Quad, Results, SCIEX information, Toxicology, ZenoTOF 7600 systemEach year, the Drug Enforcement Administration (DEA) Special Testing and Research Laboratory publishes an Emerging Threat Report. The data contained in the report is updated quarterly and represents a snapshot of the drug evidence seized and analyzed by the DEA in the...
Understanding MS1 Peak Intensity in ProteinPilot software by Christie Hunter | Data processing, Life Science Research, ProteinPilot, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemThe “Intensity (Peptide)” values come from LCMSReconstruct, in ProteinPilot software 5.0. It maps the RT, m/z, intensity MS1 surface to find the peak information for the peptide. The Intensity (Peptide) is a weighted sum of the heights of the isotope series at the...