One question I get asked a lot when it comes to cannabis, specifically regarding marijuana and hemp analysis, is: There are so many techniques to choose from, how do I know which one is best? I can’t emphasize enough that the Cannabis sativa plant has a complex...
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Nitrosamines: Where are we now?
Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
Easy switching of sources and LC flow regimes on the ZenoTOF 7600 system
This series of videos outlines how a user can easily switch sources and operate the system in different LC flow regimes.
Thailand cannabis legalization
Thailand has become the first southeast Asian country to legalize cannabis for medical use. Cannabis was originally introduced into Thailand from India, and until it was outlawed in the 1930s, it was historically used as a kitchen condiment, medicine and source of fiber.
Uploading and using transcriptomics data in the OneOmics suite
RNA experiments can be created in the OneOmics suite for multi-omics analyses, enabling integration of transcriptomics data and proteomics data for biological insight. To build RNA experiments, either CloudConnect for PeakView software 2.2 or BaseSpace (Illumina) can...
Downloading results from SCIEX Data Store or BaseSpace
Once your data processing sessions have completed, the results files are saved back to either SCIEX Data Store or BaseSpace. These can be downloaded from the cloud to your desktop for additional analysis. Please see these community posts to learn more: Explaining the...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
The top 5 questions to ask when investing in accurate mass technology for forensic toxicology workflows
Are you considering the purchase of a high-resolution accurate mass (HRAM) instrument for your forensic toxicology lab? To help ensure you invest in a solution that ideally meets your needs, ask yourself the following key questions. 1. How do I ensure my results...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Break the routine: SCIEX OS-MQ improves your quantitation workflows
Advances in today’s technology have resulted in a need for higher and faster sample throughput, with increasing number of measured analytes per sample. The new SCIEX OS-MQ software breaks the routine and takes quantitation workflows to a new level. Key features...
Stop Fumbling Around in the Dark: Try LC-MS/MS for Designer Drugs in Forensic Samples
Imagine being blindfolded, sent into a large (dark) room filled with obstacles and challenged to find an item, but you don’t know what that item is, and you have never seen it before. Then you must do the same again the next day, but you are looking for a different...
Something’s in the Water: Tackle Your PFAS Analysis
Exposure to per- and polyfluoroalkyl substances (PFAS) residues could be dangerous. These chemicals have been linked to a variety of adverse health effects including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression,...
5 Reasons Why Mass Spec is Transforming Clinical Labs
According to the American Clinical Laboratory Association, more than 7 billion clinical lab tests are performed in the U.S. every year. While mass spectrometry represents only a fraction of the clinical applications, there are a growing number of tests where mass...
Save Effort. Save Time. Consolidate Your BioTherapeutic Quality, Safety, and Efficacy Assessments with One Direct LC-MS MAM Assay.
In a previous blog, we learned how you could Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM). Based on the well-known technique of peptide mapping, a Liquid Chromatography-Mass Spectrometry-based MAM workflow (LC-MS MAM) enables...
Metabolism and Biotransformation – What Are You Missing?
Are you looking to improve your MetID studies? Want to achieve the productivity and throughput you need to keep your projects moving and have complete confidence that you’re not missing any low level or parent-like metabolites in your sample? In this blog, we’re...
Biologics Characterization: Intact and Subunit Mass Analysis
When All You Need Is Range – Mass Range, Dynamic Range, and the Complete Range Launching the best possible product in the shortest time possible is key for pharmaceutical companies like you. As you know, nearly every process throughout the biologics development cycle...
Now You Can Overcome Your Food and Environmental Testing Obstacles
How do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Unraveling the Metabolome
Dr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...
It’s Time to Stop Fraudulent Food Reaching the Consumer with LC-MS/MS
If you are reading this blog, it is likely that you are fully acquainted with food fraud, but let’s just take a moment to set the scene. Food fraud is by no means a new phenomenon and goes as far back as the middle ages, with the concept of tampering or...
Product Quality Assessments of Biotherapeutics Using LC-MS MAM
Why LC-MS MAM?The Liquid Chromatography-Mass Spectrometry Multiple Attribute Methodology (LC-MS MAM) is a technique that is quickly gaining traction in the development and manufacturing of biopharmaceuticals. But what exactly is MAM? As researchers describe in a...
Ion Formation Control Is the Key to Increasing System Robustness
Traditional mass spectrometry ionization methods such as electronic spray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), are popular methods for detecting the molecular weight of proteins, peptides, and other biologics. The reason being both...
Why You Need Mass Spec for Veterinary Drug Residue and Antibiotic Analysis
As hospitals struggle with increasingly hard-to-treat antimicrobial resistance (ARM) bacterial infections, related deaths now exceed 700,000 per year globally and are predicted to reach 10 million per year by 2050. There’s no denying that these statistics are both...
Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM)
The effort to fully characterize and release a biotherapeutic to the market can be onerous. Typically, many tests are required to identify and monitor various attributes of the final product in order to ensure the safety and efficacy of the drug. These product quality...
Solving the Mystery of Forensic Quantitative Analysis
Why You Need Differential Mobility Spectrometry for Forensic Mass Spec Analysis Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of...
Calling all Bioanalysts: We’re Making Bioanalytical Selectivity Challenges History
High selectivity is a key component of successful quantitative bioanalysis. As a bioanalyst, we need consistently accurate and robust quantitation of small molecule therapeutics and metabolites. Challenged by complicated matrix interferences, high baseline signal, and...
The Latest and Greatest for Improving Lipidomic Analysis by Mass Spectrometry
Differential Mobility Separation (DMS) resolves multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Lipidomics research has progressed rapidly in...
Out with the “If it Ain’t Broke, Don’t Fix it” Approach. In with Remote Monitoring.
Often by the time you’re aware of a problem, it’s too late, and disaster has already struck. You’re forced to pick up the pieces—downtime, reduced productivity and lost data. When your PC goes down, IT comes to the rescue. That’s a reactive approach. In many cases, IT...
Increase your Lab’s ROI with Remote Monitoring Service for SCIEX LC-MS Systems
Like most organizations, your lab is likely thinking about ways to reduce costs and maximize profits.If so, keep in mind that no matter your area of research, sample volume or locations, remote monitoring services can make a difference in yearly maintenance...
SWATH Acquisition: A Step Closer to Unravelling the Opioid Puzzle
Drug overdose has become one of the leading causes of death of Americans under 50. If that’s not bad enough, let’s put this into perspective. America makes up only 4% of the world population. In 2015, it recorded 52,400 drug-related deaths, which is about 27% of the...