The journey to mass spectrometry (LC-MS/MS) adoption from immunoassay can be complicated, but certainly rewarding. While immunoassay has been considered the default methodology for decades, they can be susceptible to interferences and cross-reactivity, especially for...
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New features in OneOmics suite
I just wanted to thank the readers here, both the OneOmics suite users who’ve shared their time and watched OneOmics grow, and for all the talented developers and scientists who’ve made OneOmics suite what it is today.
Assess the performance of the Echo® MS system
To obtain the best, most reproducible results using the Echo MS system, it is important to select the best solvent for your analyte and matrix and to ensure the flow rate is optimized for your solvent. Please review this flow rate optimization community post to...
Merging two FASTA files
There is an easy way to merge two FASTA files together. Open notepad and type this string: type %*>"newfile.fasta" Enter any name for the FASTA file between the quotes. Save the file as: Merge FASTA files.bat Copy the two files you want to merge into the same...
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
Due to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
Importing acquisition methods from Analyst software to SCIEX OS software
The SCIEX Triple Quad 7500 system is the first nominal mass instrument to be released completely on SCIEX OS software. Moving to a new software solution can be time consuming with the need to transfer numerous methods to the new platform. SCIEX OS software helps...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Unraveling the Metabolome
Dr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...
It’s Time to Stop Fraudulent Food Reaching the Consumer with LC-MS/MS
If you are reading this blog, it is likely that you are fully acquainted with food fraud, but let’s just take a moment to set the scene. Food fraud is by no means a new phenomenon and goes as far back as the middle ages, with the concept of tampering or...
Product Quality Assessments of Biotherapeutics Using LC-MS MAM
Why LC-MS MAM?The Liquid Chromatography-Mass Spectrometry Multiple Attribute Methodology (LC-MS MAM) is a technique that is quickly gaining traction in the development and manufacturing of biopharmaceuticals. But what exactly is MAM? As researchers describe in a...
Ion Formation Control Is the Key to Increasing System Robustness
Traditional mass spectrometry ionization methods such as electronic spray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), are popular methods for detecting the molecular weight of proteins, peptides, and other biologics. The reason being both...
Why You Need Mass Spec for Veterinary Drug Residue and Antibiotic Analysis
As hospitals struggle with increasingly hard-to-treat antimicrobial resistance (ARM) bacterial infections, related deaths now exceed 700,000 per year globally and are predicted to reach 10 million per year by 2050. There’s no denying that these statistics are both...
Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM)
The effort to fully characterize and release a biotherapeutic to the market can be onerous. Typically, many tests are required to identify and monitor various attributes of the final product in order to ensure the safety and efficacy of the drug. These product quality...
Solving the Mystery of Forensic Quantitative Analysis
Why You Need Differential Mobility Spectrometry for Forensic Mass Spec Analysis Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of...
Calling all Bioanalysts: We’re Making Bioanalytical Selectivity Challenges History
High selectivity is a key component of successful quantitative bioanalysis. As a bioanalyst, we need consistently accurate and robust quantitation of small molecule therapeutics and metabolites. Challenged by complicated matrix interferences, high baseline signal, and...
The Latest and Greatest for Improving Lipidomic Analysis by Mass Spectrometry
Differential Mobility Separation (DMS) resolves multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Lipidomics research has progressed rapidly in...
Out with the “If it Ain’t Broke, Don’t Fix it” Approach. In with Remote Monitoring.
Often by the time you’re aware of a problem, it’s too late, and disaster has already struck. You’re forced to pick up the pieces—downtime, reduced productivity and lost data. When your PC goes down, IT comes to the rescue. That’s a reactive approach. In many cases, IT...
Increase your Lab’s ROI with Remote Monitoring Service for SCIEX LC-MS Systems
Like most organizations, your lab is likely thinking about ways to reduce costs and maximize profits.If so, keep in mind that no matter your area of research, sample volume or locations, remote monitoring services can make a difference in yearly maintenance...
SWATH Acquisition: A Step Closer to Unravelling the Opioid Puzzle
Drug overdose has become one of the leading causes of death of Americans under 50. If that’s not bad enough, let’s put this into perspective. America makes up only 4% of the world population. In 2015, it recorded 52,400 drug-related deaths, which is about 27% of the...
Greater uptime equals higher productivity
In the old days, if you wanted to monitor your lab’s data, you would either remain by your instrument as long as it took to complete the sample run or dial-in via a telephone modem. Neither option, however, offered much in the way of enhancing productivity. Today’s...
Simplifying Polar Pesticides Within a Single Analysis
Glyphosate is a polar pesticide widely used as a garden herbicide. It is an ingredient in the world’s bestselling weed killer, which farmers consider one of their best solutions to their super weed problems. However, the chemical has become one of the most...
5 Applications That Benefit from a New Dimension in Selectivity
Mass spectrometry can provide exceptional sensitivity, selectivity, resolution, throughput, and mass accuracy, but certain applications demand additional levels of selectivity. This is where differential ion mobility technology comes in. It delivers highly-selective,...
Screening Food for Allergens Using LC-MS/MS Analysis
Browse the shelves of any grocery store, and you may get a false sense of security when it comes to ingredient lists. As much as consumers want to trust labels, the truth is, food products could contain mislabelled ingredients, such that they trigger an allergic reaction with serious detrimental effects including discomfort, pain sickness and in some instances, death. Manufacturers, however, do not want to risk their reputation and consumer safety over a false label. As such, there must be some sort of verification to support such an action
4 Reasons Why Your Lab Needs Remote Monitoring
You know the drill, lab managers are always seeking new solutions to keep their labs running at peak performance and instrument or system disruptions can be detrimental. Wouldn’t it be nice if there were a way to connect to your lab from anywhere securely and to stay ahead of potential instrument problems? By using remote monitoring, labs are now able to respond to issues quickly and efficiently, productively reducing downtime.
Testing for a Variety of Bath Salts is a Necessity for Forensic Labs
To date, when it comes to testing urine or oral fluids in the workplace not all psychoactive substances can be detected due to evolving substitutions. As legislation changes, so too do chemical formulations. Therefore researchers, like the authors of the following publication, A Validated Method for the Detection of 32 Bath Salts in Oral Fluids, published by Oxford Academic, analyze compounds using the best available methods so they can cast a wider net.
Empowering Your Lab with a Proactive Approach
Do you stay in the lab day and night, waiting for a sample run to finish? Or do you set your instrument to run and trust that it will operate as intended while you are away? Is there a way you can have a support network behind you to help to ensure the smooth operation of your instruments?
Vitamin D Analysis Made Simple
Last month, Dr. Phil Levy, a clinician, professor, and researcher at Wayne State University, was invited to SCIEX to lecture on ‘Vitamin D Measurement and Implications for Patient Care.’ His message was simple and very clear: Vitamin D testing is here to stay!