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The Echo® MS system is specifically designed to be compatible with a variety of automation options to allow labs the flexibility to personalize their setup to meet their specific needs. To help you make the best decisions for your own lab, here are the answers to some...
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Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Unlock the benefits of nominal mass spectrometry for NPS analysis
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
High mass tuning calibration for ZenoTOF 7600
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Metabolite identification and peace of mind
Managing metabolite identification (Met ID) studies is challenging, so what is at the top of your priority list as you plan the year ahead? Ensuring you have the data needed to manage product safety, meeting deadlines, staff recruitment and training, maintaining compliance, capital expenses, or something else?
Automation integration for the Echo® MS system
The Echo® MS system is specifically designed to be compatible with a variety of automation options to allow labs the flexibility to personalize their setup to meet their specific needs. To help you make the best decisions for your own lab, here are the answers to some...
Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS
Producing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand.
It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.
sMRM Pro Builder template tutorial
The sMRM Pro Builder template is an Excel-based tool that can help you implement large panels of analytes in your lab. The Excel sheet will take your preliminary experimental results and compute retention times, retention time window widths and dwell time weighting to optimize your targeted assay.
How to share your results with collaborators
As multi-omics research is often highly collaborative, tools for rapidly sharing important results files are needed to drive scientific progress. The SCIEX Data Store in the OneOmics suite enables you to not only organize your uploaded multi-omics data files into...
Thailand cannabis legalization
Thailand has become the first southeast Asian country to legalize cannabis for medical use. Cannabis was originally introduced into Thailand from India, and until it was outlawed in the 1930s, it was historically used as a kitchen condiment, medicine and source of fiber.
Advanced analytics for mAb variants
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Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
Accurate mass LC-MS/MS for PFAS analysis without needing a blockbuster budget
If you’ve been following our recent blogs, you’ve probably seen quite a bit on how per- and polyfluoroalkyl substances (PFAS) are shaking up both the food and environmental industry. Even if you’ve not been following our blogs, you’ve probably seen a lot of media...
A rising star in food allergen research: proteomics of shellfish allergen
It’s important to know what you’re eating, especially if you suffer from a food allergy.
About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
Routine cannabis screening is here. Will your lab reap the benefits?
Fast, accurate, and robust solution for routine commercial cannabis testing
As the world debates cannabis legalization for therapeutic applications and recreational use, the trends are shifting. Medicinal use of cannabis is legal in an increasing number of countries worldwide, including 33 states and the District of Columbia in the United States. Uruguay was the first country in the world to legalize the sale, cultivation, and distribution of cannabis in 2013. In the United States, Washington and Colorado were the first to fully legalize cannabis in 2012. By the end of 2019, 10 states have legalized recreational use for adults over the age of 21, with 64% of Americans favoring the move
Keep up with fentanyl and its analogs: Failure to do so is not an option.
Fentanyl is one of the most well-known synthetic opioids that has been in the spotlight lately—and not for good reasons. The World Drug Report 2019 reveals that there have been more than 47,000 opioid overdose deaths in the United States in 2017. This is an increase...
Hemp, marijuana, CBD and THC: what’s the difference?
Cannabis refers to a genus of flowering plants originating from Asia.1 It's also an umbrella term that includes both marijuana plants and hemp plants, among others. With the flurry of legalization across the United States, CBD and THC derived products have been thrown...
Mysterious Vaping Detectives Part 2
In our last blog, I gave you some current highlights about the mysterious vaping illness that was making headlines (and still is). The condition now known as, e-cigarette or vaping, product use-associated lung injury (EVALI) has sickened thousands and killed 57...
Trends shaping global environmental analytical testing
The only certainty in a changing environmental landscape Despite a 38-fold increase in environmental laws put in place around the world since 1972, the future of our planet is under the spotlight like never before. Mitigating climate change has arrived as our world's...
Mass spectrometry as a forensic science tool in 2020
There’s no doubt about it: forensics is at the front line of the criminal justice system. It’s where analytical chemistry has the power to fight crimes. It’s fascinating! But what excites me is how quickly things change and the speed of innovation. Just think about...
Microflow for metabolite ID: a win all around
Over the last several years there has been a slow and steady progression within the LC-MS community to move traditional high-flow applications to lower flow rates. In particular, moving into the microflow regime has proven to be a simple adjustment in methodology that...
A year of cannabis in Canada. Where are we and what’s next?
It’s been a momentous year for the cannabis industry in Canada. Not only did the country legalize cannabis with the Canadian cannabis law in October 2018, but it has also taken a giant leap in setting up a multi-billion dollar market from scratch. The progress made...
Take 5 with SCIEX Global Technical Marketing’s Pierre Negri
With the rise of Novel Psychoactive Substances (NPS), or designer drugs, in the past decade, forensic toxicologists are being tested like never before. It seems like as soon as one analog is identified, another is synthesized. These new chemicals share structures with...
When is a triple quadrupole not a triple quadrupole?
Answer: When it’s a QTRAP® In today’s modern and frenzied analytical laboratories, triple quadrupole mass spectrometers (MS) are the ‘workhorse,’ frontline instrument for carrying out quantitative assays from drug discovery to food safety. To get the best selectivity...
Turbo charging your LC-MS/MS analysis
Would you like to take your LC-MS/MS analysis from 0 to 3 mL/min without the complexity of changing probes or splitting the LC flow? Then take a look into the Turbo V ion source from SCIEX. Introduced more than 15 years ago, the Turbo V ion source continues to be a...
Separation anxiety: Choosing the best approach to quantify the lipidome
Front-End Solutions for Lipid AnalysisWhich method should you choose? Lipids are a diverse group of compounds that serve many purposes. They are the basis for key biological entities including cell membranes, hormones, and lipoproteins and are involved in a variety...
Your 3 most googled queries about cannabis testing answered
I did some digging on Google and decided to help answer the top 3 most searched queries about cannabis testing methods and technology, for both marijuana and hemp. 1. What equipment should I use to test my cannabis and hemp samples for mycotoxins,...
Boar taint isn’t so simple
The title says it all. Boar taint is a complex subject. For some, it’s not an issue. Others argue that it’s one of the biggest challenges to pork quality. It’s a very subjective response. In her blog, Dr. Laura Hancox illustrates the striking difference between the...
A beginner’s instrumentation guide to cannabis analysis
One question I get asked a lot when it comes to cannabis, specifically regarding marijuana and hemp analysis, is: There are so many techniques to choose from, how do I know which one is best? I can’t emphasize enough that the Cannabis sativa plant has a complex...
Worth the Journey – From Immunoassay to LC-MS/MS Adoption
The journey to mass spectrometry (LC-MS/MS) adoption from immunoassay can be complicated, but certainly rewarding. While immunoassay has been considered the default methodology for decades, they can be susceptible to interferences and cross-reactivity, especially for...
Calling SCIEX Software Users: Windows 10 Support for all SCIEX Software
As a researcher in a busy lab, the software driving your work is critical to your success, and the timely transition of SCIEX applications to Windows 10 is no exception. In early 2020 Microsoft will be ending Windows 7 support, and we want you to know we are taking...
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