I have a turbo v ion source that shows a glowing blue/purple light at the tip of the Heated Nebulizer corona discharge needle, even when it is not in use and turned out of ion path as it should be when using TIS probe. It only happens in negative mode. It is not arcing to the cutain plate, just a slight noticeable glow at the tip of the corona needle when observed through the front window. My FSE has rebuilt the HN probe and components and also installed a new TIS probe. Still glows when in negative mode. Note also having poor sensitivity in negative mode as well and jagged peak shapes during infusion. Any ideas? Are the symptoms related?
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Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Loss the contact closure signal
our 7600 couple with nanoLC Ultimate 3000 via contact closure. it has run without any loss connection during the batch. Just yesterday, the last injection keep equilibrating system until the LC finished the gradient run. We closed the software and power off LC and MS then started again but it did not help. The Dionex engineer also checked their LC and triggerring cable found both are ok.
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Methods for OPI electrode cleaning for Echo® MS system electrodes
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New features in OneOmics suite
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Advanced analytics for mAb variants
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What are my normalization options in MarkerView software and when should I use them?
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Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
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Top questions about the exposome of PFAS revealed
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What’s in your citrus oil?
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Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
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The honey sting
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A new generation of therapeutic modalities
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Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...