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Page 35 of 61
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000 clinical trials involving gene therapies or oligonucleotides currently in various stages, and 11 gene therapy […]
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, Pharma, power, protein, rapid, system, technology, time, variant, work
June 8, 2020
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information due to problems with either very small or very large protein and peptide retention. Unfortunately, slow going methods like […]
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
May 18, 2020
Are we proactively solving the nitrosamine crisis?
In my previous blog, I spoke about the FDA recall of angiotensin II receptor blockers like losartan. This recall was due to the presence of genotoxic nitrosamines. Is a proactive approach the way to mitigate risk? Recently, the FDA has re-issued the 2018 guidance to industry, “M7(R1) assessment and control of DNA reactive (mutagenic) impurities […]
Tags: APIs, Drug manufacturing, Genotoxic Impurities, Nitrosamines, Pharma, quantification
May 8, 2020
Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, Pharma, power, protein, rapid, system, technology, time, variant, work
May 7, 2020
Packaging with PFAS is not all it’s wrapped up to be
In the 1930s, a research chemist accidentally created polytetrafluorethylene (PTFE). The discovery put him in the National Inventors Hall of Fame when PTFE was later commercialized under the trade name Teflon. Nobody anticipated the impact this invention would have on the world. It was the first-ever compound in the family now known as per- and polyfluoroalkyl substances (PFAS). Many […]
Tags: Environmental testing, FCM, Food Testing, Forever chemicals, PFAS, PFAS Food packaging
April 24, 2020
Accurate mass LC-MS/MS for PFAS analysis without needing a blockbuster budget
If you’ve been following our recent blogs, you’ve probably seen quite a bit on how per- and polyfluoroalkyl substances (PFAS) are shaking up both the food and environmental industry. Even if you’ve not been following our blogs, you’ve probably seen a lot of media coverage like this one about how PFAS is affecting water supplies. Or perhaps you’ve […]
Tags: biotherapeutic development, blaze, charge, company, couple, development, Environmental, Food / Beverage, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
April 14, 2020
A rising star in food allergen research: proteomics of shellfish allergen
It’s important to know what you’re eating, especially if you suffer from a food allergy.
About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
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April 13, 2020
When fungicides impact more than just fungi, is chlorothalonil a concern?
Plant protection products have sowed seeds of controversy within the agricultural, scientific and regulatory communities. Conversations seem to surround the impact of these chemicals on the ecosystem. Looking at the bee colony collapse disorder, we posted a blog discussing possible stressor neonicotinoids. Herbicides such as glyphosate are also believed to have contributed to the problem.1 If that’s not enough, […]
Tags: food safety, Food Testing, Fungicides, Neonicotinoids, Pesticides, residue testing
March 25, 2020
Routine cannabis screening is here. Will your lab reap the benefits?
Fast, accurate, and robust solution for routine commercial cannabis testing
As the world debates cannabis legalization for therapeutic applications and recreational use, the trends are shifting.  Medicinal use of cannabis is legal in an increasing number of countries worldwide, including 33 states and the District of Columbia in the United States. Uruguay was the first country in the world to legalize the sale, cultivation, and distribution of cannabis in 2013. In the United States, Washington and Colorado were the first to fully legalize cannabis in 2012. By the end of 2019, 10 states have legalized recreational use for adults over the age of 21, with 64% of Americans favoring the move
Tags: biotherapeutic development, blaze, charge, company, couple, development, Food / Beverage, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
February 24, 2020
Keep up with fentanyl and its analogs: Failure to do so is not an option.
Fentanyl is one of the most well-known synthetic opioids that has been in the spotlight lately—and not for good reasons. The World Drug Report 2019 reveals that there have been more than 47,000 opioid overdose deaths in the United States in 2017. This is an increase of 13% from the previous year. The same report also draws […]
Tags: biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
February 19, 2020
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